Firstly, I must apologise for my blog entry drought of late. This is directly attributable to my ME/CFS prohibiting me (since January) from using a computer for any meaningful period of time. I have been experiencing a mild ‘virus?’ for the past several days which paradoxically has enabled me to write this blog entry. It is somewhat a shaded irony that my cognitive impairment inevitably (yet temporarily and mildly) improves when I experience viruses.
Nexavir: The Results
I wrote a blog entry last year (https://livingwithchronicfatiguesyndrome.wordpress.com/2010/10/25/nexavir-kutapressin-for-cfs/) documenting the use of Nexavir as a treatment for ME/CFS. Approximately 1 month ago I ceased the daily Nexavir injections after trialling this treatment for a period of 7 months. The first 4 months of treatment involved a 2ml injection of Nexavir daily while the final 3 months of treatment encompassed a pulsing dose structure of 1ml, 3ml, 1ml, 3ml etc. I did not experience any distinctive positive or adverse affects as a consequence of the Nexavir treatment. My lack of responsiveness to Nexavir may partially be attributable to my negative (or low titre) test results to; HHV6 early antigen, HHV6 IgG, HHV6 IgM, EBV early antigen and EBV VCA ELISA. Studies have indicated that Nexavir has the greatest efficacy in patients with high EBV-EA IgG titer levels and in vitro evidence also suggests that high HHV-6 titer levels may be reduced by Nexavir.
L-Serine is an amino acid which former Adelaide CFS specialist, Dr. Buttfield, believes should help 60% of CFS patients significantly. In the past I have consumed a daily dose of L-Serine amounting to 500mg for the period of 3 months (as part of Energy Revitalization System powder.) This did not produce any noticeable effects. Dr. Buttfield recommends that patients begin taking L-Serine at a 500mg dose and titrate this dosage upwards towards a maximum daily dose of 2g. I have been taking a pure L-Serine powder for the past 2 weeks and I’m still in the process of increasing the daily dosage. I will write a subsequent blog entry detailing whether L-Serine had a beneficial effect on my ME/CFS.
During March I began taking the expectorant ‘Guaifenesin’ for the period of a month. Guaifenesin is most widely known in the Fibromyalgia and ME/CFS domain as part of Dr. Paul St. Amand’s controversial protocol encompassing salicylate avoidance. For the record, I am vehemently opposed to Dr. St. Amand’s protocol. My motives for trialing Guaifenesin stemmed from its expectorant effects and potential mechanism of action in inhibiting chronic sinusitis. My secondary motives for attempting this treatment involved its potential to inhibit platelet aggregation. Guaifenesin lowers uric acid levels which are already subpar in many ME/CFS patients hence I took Guaifenesin in tandem with brewer’s yeast (which raises uric acid levels.) I began taking 200mg of Guaifenesin and increased this dose to 600mg. After no effect on my high volume of mucus discharge or sinus related symptoms, I ceased taking Guaifenesin after one month. High doses of Guaifenesin may cause kidney stones and anecdotal reports indicate that many Fibromyalgia and ME/CFS patients experience a worsening of symptoms while taking Guaifenesin. I did not notice any positive or adverse effects as a consequence of taking Guaifenesin.
Piracetam and Choline Citrate
I wrote a past blog entry documenting the potential usefulness of Piracetam as a treatment for ME/CFS (https://livingwithchronicfatiguesyndrome.wordpress.com/2011/04/04/piracetam-for-mecfs/) For the past month, I have taken 4.8g of Piracetam daily in three smaller doses of 1.6g consumed at eight hour intervals. I have also taken choline citrate (500mg a day, taken in a single dose) in tandem with the Piracetam. The reasoning behind combining these treatments involves the synergistic effects that Piracetam has when consumed concurrently with choline citrate (regarding mechanism of action as a nootropic.) After one month of these treatments I am yet to notice any positive or adverse effects. I plan to continue these synergistic treatments for the total period of 3 months.
I have a plethora of future treatments lined up to trial including drugs that are supposedly effective against Raynaud’s phenomenon and improving cerebral circulation levels. I will hopefully write more about these and other treatments when I obtain them.