On the 29th of October 2009 I began taking oxymatrine tablets. My preferred brand of oxymatrine was Equilibrant which also contains various immune modulators. Doctor Chia began producing the Equilibrant form of oxymatrine after becoming concerned with the purity of some of the other brands. I was unable to acquire the Equilibrant brand hence I ordered the White Tiger brand.
The White Tiger brand contains 200mg of oxymatrine per tablet. My dosing structure is flexible based on any reaction to the oxymatrine however at the moment stands at:
100mg each day for 2 weeks. The tablet is to be taken with water before or with meals.
100mg 2x a day for 2 weeks.
200mg at am and 100mg at pm for 2 weeks.
200mg at am and 200mg at pm for the remaining 6 weeks.
Note that for the White Tiger brand, it is necessary to break to tablet in half in order to obtain a 100mg dose of oxymatrine.
The above dosing schedule is preliminary as over half of those taking oxymatrine experience some sort of side effect. This may include headache, fatigue or an increase in severity of some of your current symptoms. If I don’t experience any side effects I will follow the above dosing structure. If I do experience side effects I will adjust the dosing structure accordingly based on the severity of side effects and what dose of oxymatrine the side effects occur at.
I will complete the oxymatrine course after 3 months if I experience no improvement of my current symptoms however if I experience improvement I will extend the dose accordingly.
I must stress that it is imperative to slowly increase the dose. I have so far taken oxymatrine for 5 days and on day 2 I became very dizzy. This lasted for around 4 hours starting about 10minutes after taking a 100mg dose of oxymatrine.
Facts about Oxymatrine
Oxymatrine is derived from the Sophora plants. It has been shown to have some degree of antiviral properties. It is often used in treating Hepatits B due to its suggested ability to reduce liver damage and reduce viral load. It has also been suggested that oxymatrine can increase blood flow and in China it is sometimes used as an anti-cancer drug.
Doctor Chia is the main advocate of oxymatrine and has done a study on its usefulness. The results of the study are one of the main reasons that I decided to try taking it. The results of Dr Chia’s oxymatrine studies:
52% of those taking it showed some sort of improvement.
2% of those using placebo showed some sort of improvement
52% of those taking oxymatrine showed some improvement in the second trial.
Dr Chia has given to herb to over 350 patients and says that 52% of patients experience some degree of improvement.
The use of oxymatrine is intended for those CFS patients who test positive to enterovirus. It can be quite expensive to determine if you have enterovirus. Some of the blood tests for enterovirus are not considered sensitive enough. Dr Chia often gets stomach biopsies performed to determine the virus in patients.
Positive results on coxsackie b or echovirus antibody tests can also justify trying oxymatrine. I have decided to take oxymatrine without having any of these tests done. I figure that I can spend thousands of dollars getting these tests done and then try oxymatrine or try oxymatrine without getting the tests done. If I am negative for enterovirus, coxsackie b and echovirus, then oxymatrine still may be of use for its antiviral affects.
Dr Chia is very interested in the patient’s onset of CFS. Mine seemed to be a gradual onset with coughing up mucus an isolated symptom for 3 months until fatigue began to set in. This coughing up mucus has continued from the onset to the present and increased in severity to the point of me currently coughing up mucus 700 times plus a day. A common onset of enterovirus is upper respiratory symptoms hence I am interested in taking oxymatrine. I do suspect that the upper respiratory symptoms of enterovirus last only a few weeks based on case studies I have read. The 4 years of my upper respiratory symptoms seems to indicate that maybe my onset isn’t consistent with enterovirus however I am still willing to take oxymatrine.
Oxymatrine should not be used in those with autoimmune tendencies or known seizure disorders. There is also a risk or neurological toxicities in those taking oxymatrine. I must stress that if you intend to take oxymatrine, I recommend doing it under medical guidance. It is also very important to increase the dose slowly.
I will continue to update this blog with any affects oxymatrine has on me.
A good source of discussion between those who have already taken oxymatrine can be found at the HHV 6 foundation forums at http://hhv6foundation.proboards.com/index.cgi?board=antiviral&action=display&thread=200&page=1
You need to sign up for the forums in order to view topics such as this one.
The Phoenix Rising page also has a good amount of information on oxymatrine including an interview with Dr Chia http://aboutmecfs.org/Int/IntChia1.aspx
And some general information about oxymatrine http://aboutmecfs.org/Trt/TrtOxymatrine.aspx